SML0352
PFI-1
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 1403764-72-6
Synonym(S): 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide, PF-06405761
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML0352-5-MG | In Stock | ₹ 10,132.20 |
| 25 MG | SML0352-25-MG | In Stock | ₹ 38,926.70 |
SML0352 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 10,132.20
GST (18%): ₹ 1,823.796
Total Price: ₹ 11,955.996
Quality Level
100
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccccc1S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
InChI
1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20)
InChI key
TXZPMHLMPKIUGK-UHFFFAOYSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Sigma Aldrich Fine Chemicals Biosciences PFI-1 >=98% (HPLC) | 1403764-72-6 | MFCD22580416 | 5MG | -- | ₹ 13,628.57 | ||
eMolecules Ambeed / 2-Methoxy-N-(3-methyl-2-oxo-1234-tetrahydroquinazolin-6-yl)benzenesulfonamide / 1mg / 515725495 / A280183 / / 1403764-72-6 / MFCD22580416 / 347.390 / C16H17N3O4S | -- | ₹ 2,604.14 | ||
Sigma Aldrich Fine Chemicals Biosciences PFI-1 >=98% (HPLC) | 1403764-72-6 | MFCD22580416 | 25MG | -- | ₹ 37,396.02 | ||
1403764-72-6 | Pfi-1 | -- | ₹ 1,424.00 - ₹ 69,598.00 |
Related Products
Description
- Application: PFI-1 has been used as a bromodomain inhibitor in breast cancer cell line MCF7[1] dechorionated zebrafish embryos.[2] It has also been used in human peripheral blood mononuclear cells (PBMCs), to inhibit the release of interleukin-6 in lipopolysaccharide (LPS) challenge assay.[3]
- Biochem/physiol Actions: PFI-1 is a quinazolinone inhibits androgen receptor (AR) mediated signaling in prostate cancer cells.[4] It elicits minimum toxicity and is effective for anti-HIV-latency therapy.[5] In leukemia cells, PFI-1 inhibits Aurora B kinase and promotes caspase-dependent apoptosis.[6]
- Features and Benefits: PFI-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
- Other Notes: PFI-1 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PFI-1 probe summary on the Chemical Probes Portal website.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable