PC3451SET
MilliporeSigma™ Orexin A (14-33) (Ab-1), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set
Manufacturer: MilliporeSigma™
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Antigen
Orexin A (14-33) (Ab-1)
Classification
Polyclonal
Formulation
100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen
a synthetic peptide (CRLYELLHGAGNHAAGILTL) corresponding to amino acids 14-33 of human orexin A
Regulatory Status
RUO
Test Specificity
Recognizes orexin A in mouse and rat brain. Supplied with a control peptide.
Target Species
Bovine, Human, Mouse, Rat
Form
Purified
Applications
ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
1 Set
Primary or Secondary
Primary
Includes
100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage
2°C to 8°C
Isotype
IgG
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Description
- Specifically detects Orexin A (14-33) (Ab-1) Clone: in Bovine, Human, Mouse, Rat samples, and it is validated for ELISA, Immunofluorescence, Immunohistochemistry (Frozen) The hypothalamus has been shown to play a central role in the regulation of energy homeostasis and in the control of feeding behavior
- Two homologous peptides have recently been identified for which the message and protein have been localized to the lateral hypothalamus
- Orexin A (hypocretin 1), a 33 amino acid peptide, and orexin B (hypocretin 2), a 28 amino acid peptide, are both encoded by a single mRNA transcript
- These peptides stimulate food consumption in a dose-dependent manner when administered intracerebroventricularly, and precursor mRNA levels are upregulated upon fasting
- In addition to the orexins (hypocretins), two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides
- Competitive radioligand binding assays suggest that the orexin receptor-1 is selective for orexin A, while orexin receptor-2 is nonselective for both peptides.