MilliporeSigma™ Vanilloid Receptor Like Protein-1 (744-761), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set
Manufacturer: MilliporeSigma™
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Antigen
Vanilloid Receptor Like Protein-1 (744-761)
Classification
Polyclonal
Formulation
100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Immunogen
a synthetic peptide (KNSASEEDHLPLQVLQSP) corresponding to amino acids 744-761 of rat vanilloid receptor like protein 1, conjugated to KLH
Regulatory Status
RUO
Test Specificity
Recognizes the ∽98kDa (doublet) vanilloid receptor like protein-1 in rat spinal cord extract. Supplied with a control peptide (100μg size only).
Target Species
Mouse, Rat
Form
Purified
Applications
Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
1 Set
Primary or Secondary
Primary
Includes
100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Content And Storage
2°C to 8°C
Isotype
IgG
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Description
- Specifically detects Vanilloid Receptor Like Protein-1 (744-761) Clone: in Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Frozen), Immuno Blotting The detection of noxious stimuli (chemical, mechanical, or thermal), a process referred to as nociception, occurs predominantly at the peripheral terminals of primary afferent neurons
- This information is ultimately transmitted to the central nervous system to evoke a perception of pain which initiates appropriate protective reflexes
- Vanilloid-containing compounds which include capsaicin, the active ingredient in hot chilli peppers, selectively depolarize nociceptors to activate the nociceptive pathway
- The receptor for capsaicin, vanilloid receptor 1 (VR1), has been identified as a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels
- The vanilloid receptor 1 protein functions both as a receptor for capsaicin and a transducter of noxious thermal stimuli
- Immunocytochemical and mRNA localization studies suggest that VR1 protein is localized to small-diameter sensory neurons within the dorsal root ganglia and nerve terminals in the dorsal horn
- A capsaicin-receptor homolog has recently been identified, designated the vanilloid-receptor-like protein 1 (VRL-1)
- VRL-1 is activated by high temperatures and is expressed in medium- to large-diameter neurons within sensory ganglia.