PC3471SET
MilliporeSigma™ Serotonin 3 (5-HT3) Receptor (444-457), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set
Manufacturer: MilliporeSigma™
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Antigen
Serotonin 3 (5-HT3) Receptor (444-457)
Classification
Polyclonal
Formulation
25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen
a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Regulatory Status
RUO
Test Specificity
Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Target Species
Mouse, Rat
Form
Purified
Applications
Immunohistochemistry (Frozen)
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
1 Set
Primary or Secondary
Primary
Includes
25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage
2°C to 8°C
Isotype
IgG
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Description
- Specifically detects Serotonin 3 (5-HT 3 ) Receptor (444-457) Clone: in Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen) The monoamine serotonin (5-hydroxytryptamine) mediates a variety of physiological actions by binding to a number of distinct receptors, pharmacologically classified into several major groups which differ in tissue and cellular localization, affinity for serotonin, and second messenger pathways
- The majority of these receptors stimulate a GTP-binding protein upon agonist stimulation and couple to adenylate cyclase or phospholipase C
- In contrast, the 5-HT 3 receptor is a ligand-gated ion channel that mediates a fast excitatory response
- This receptor is a member of the superfamily of ligand-gated ion channels related to the nicotinic, GABA A and NMDA receptors
- Although the 5-HT 3 receptor was initially identified from the neuroblastoma cell line NCB-20, radioligand binding studies and in situ hybridization studies have localized the 5-HT 3 receptor to a unique distribution of neurons, supporting possible roles for the receptor in cognition and sensory input
- Recent immunohistochemical analysis of the rat brain revealed a broad distribution of 5-HT 3 immunoreactivity, primarily including interneurons and motor neurons.