01-674-648
LIME Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-674-648-Each-of-1 | In Stock | ₹ 46,502.50 |
01-674-648 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
LIME
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Lime1
Gene Alias
2810038K19Rik; dJ583P15.4; FLJ20406; Lck interacting transmembrane adaptor 1; lck-interacting membrane protein; Lck-interacting molecule; lck-interacting transmembrane adapter 1; Lime; lime 1; LIME1; LP8067; RP4-583P15.5
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
72699
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9EQR5
Gene Symbols
Lime1
Immunogen
Synthetic peptide corresponding to amino acids ENVYESIKEMGL.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
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Description
- This antibody is predicted to react with rat based on sequence homology
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000
- LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells
- After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk
- Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling
- However, under some circumstances, LIME may mediate inhibitory signals.