beta-2 Microglobulin Monoclonal Antibody (B2M-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-913-Each-of-1 | In Stock | ₹ 53,400.00 |
01-675-913 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,400.00
GST (18%): ₹ 9,612.00
Total Price: ₹ 63,012.00
Antigen
beta-2 Microglobulin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P61769
Gene Symbols
B2m
Immunogen
Purified human beta-2 Microglobulin.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
Clone
B2M-01
Conjugate
Unconjugated
Gene
B2m
Gene Alias
B2m; B2-microglobulin; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; Beta2 microglobulin; beta-2 microglobulin; beta-2 microglobulin preprotein; beta2m; beta2-m; beta-2-microglobin; beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta-2-microglobulin form pI 5.3; B-F; CDABP0092; HDCMA22P; IMD43; Lactollin; Ly-m11; MHC Class I; microglobulin beta-2; Orla-B2m
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
567
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- This antibody reacts with beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin
- It will not cross-react with mouse, rabbit, canine, chicken or bovine
- Western Blot: Both reducing and non-reducing conditions
- Non-reducing conditions preferred; RIA: Use at an assay dependent concentration
- The dissociation constant of the antibody soluble beta2-microglobulin is 1.5 x 10^-8 mol/L as determined by competitive RIA
- Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I
- Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes
- Beta-2 microglobulin is also found in free form in the plasma
- The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure
- The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation
- Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells
- Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15
- A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia
- Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients
- Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.