Zap-70 Monoclonal Antibody (ZAP-03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-183-Each-of-1 | In Stock | ₹ 44,900.50 |
01-676-183 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,900.50
GST (18%): ₹ 8,082.09
Total Price: ₹ 52,982.59
Antigen
Zap-70
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P43403
Gene Symbols
ZAP70
Immunogen
Bacterially expressed fusion protein representing C-terminal part (160 amino acids) of human ZAP-70 with histidine tag
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
ZAP-03
Conjugate
Unconjugated
Gene
ZAP70
Gene Alias
70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
301348, 7535
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins
- ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation
- Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains
- Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.