MUTYH Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-626-Each-of-1 | In Stock | ₹ 46,502.50 |
01-676-626 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MUTYH
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MUTYH
Gene Alias
5730495A01Rik; A/G-specific adenine DNA glycosylase; adenine DNA glycosylase; adenine-DNA glycosylase; hMYH; MGC4416; mMYH; mutY DNA glycosylase; mutY homolog; mutY homolog (E. coli); mutY homolog alpha; Mutyh; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; mutY-like protein; Myh; OTTHUMP00000009098; OTTHUMP00000009102; rMYH; RP4-534D1.2; the full-length form type A, 5' region
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
170841, 4595, 70603
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.05% BSA and 0.02% sodium azide
Gene Accession No.
Q8R5G2, Q99P21, Q9UIF7
Gene Symbols
MUTYH
Immunogen
A synthetic peptide corresponding to amino acids 531-546 of human MYH.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bacteria, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Suggested positive control: Hela whole cell extract
- MYH (mutY homolog (E
- coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches
- Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair
- MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage
- Multiple N-terminal splice variants of MYH exist in mammalian cells
- Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival
- Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas
- MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.