Estrogen Receptor beta Monoclonal Antibody (14C8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-950-113-Each-of-1 | In Stock | ₹ 53,578.00 |
01-950-113 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,578.00
GST (18%): ₹ 9,644.04
Total Price: ₹ 63,222.04
Antigen
Estrogen Receptor beta
Classification
Monoclonal
Concentration
1.23 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
O08537, Q92731
Gene Symbols
ESR2
Immunogen
Recombinant protein corresponding to residues 1-153 of human ER beta, expressed in E. coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate
Product Type
Antibody
Isotype
IgG2b
Applications
ChIP Assay, Dot Blot, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
14C8
Conjugate
Unconjugated
Gene
ESR2
Gene Alias
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
13983, 2100
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- For immunostaining, strong ER beta staining in epithelial cell nuclei is observed, with weak to moderate staining seen in surrounding stromal and endothelial cell nuclei, and sporadic light cytoplasmic staining
- It has also been reported that this antibody has been used to detect ERb in colon and ovarian tumors
- Positive control of recombinant fusion protein
- Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described
- Human ER beta was initially cloned and characterized from testis
- Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors
- The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA
- When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins
- There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively)
- Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha
- Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues
- ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.