ALDH1L1 Monoclonal Antibody (7G8), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-959-537-Each-of-1 | In Stock | ₹ 1,22,108.00 |
14-959-537 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,22,108.00
GST (18%): ₹ 21,979.44
Total Price: ₹ 1,44,087.44
Antigen
ALDH1L1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O75891
Gene Symbols
ALDH1L1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10840
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
7G8
Conjugate
Unconjugated
Gene
ALDH1L1
Gene Alias
10-formyltetrahydrofolate dehydrogenase; 10fTHF; 10-fTHF; 10FTHFDH; 10-FTHFDH; 1810048F20Rik; aldehyde dehydrogenase 1 family member L1; aldehyde dehydrogenase 1 family, member L1; aldehyde dehydrogenase family 1 member L1; Aldh1l1; Cytosolic 10-formyltetrahydrofolate dehydrogenase; DKFZp781N0997; FBP-CI; FDH; formyltetrahydrofolate dehydrogenase; Fthfd; LOC100855730; MER57B-ALDH1L1; Neut2
Host Species
Mouse
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- Description: This 7G8 monoclonal antibody reacts with human 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) a protein involved in folate metabolism
- The cytosolic enzyme, with homology to the aldehyde dehydrogenase (ALDH) family, is involved in the conversion of 10-formyltetrahydrofolate, NADP and water to tetrahydrofolate, NADPH and carbon dioxide
- Folate metabolism is essential for cell growth and proliferation and decreased levels of folate have been implicated in neural tube defects in addition to increased cancer risk
- This isoform (1L1) is expressed in glial cells has been identified as a highly specific marker for astrocytes labeling both the cell body and processes
- Applications Reported: This 7G8 antibody has been reported for use in flow cytometric analysis, western blotting, immunohistochemical staining, and immunocytochemistry
- Applications Tested: This 7G8 antibody has been tested by immunohistochemistry on human FFPE tissue using both high and low pH antigen retrieval
- Both antigen retrieval methods resulted in staining although low pH antigen retrieval is optimal
- The antibody can be used at less than or equal to 1 μg/mL
- It is recommended that anibody be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide
- The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo
- Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.