HCN2 Monoclonal Antibody (QQA 4A6), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-969-282-Each-of-1 | In Stock | ₹ 44,500.00 |
14-969-282 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,500.00
GST (18%): ₹ 8,010.00
Total Price: ₹ 52,510.00
Antigen
HCN2
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.
O88703, Q9JKA9
Gene Symbols
HCN2
Immunogen
Peptide corresponding to aa676-710
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunohistochemistry (Frozen), Western Blot
Clone
QQA 4A6
Conjugate
Unconjugated
Gene
HCN2
Gene Alias
BCNG2, BCNG-2, brain cyclic nucleotide gated channel 2, brain cyclic nucleotide-gated channel 2, Hac1, HAC-1, HCN2, hyperpolarization activated cyclic nucleotide gated potassium channel 2, hyperpolarization activated cyclic nucleotide-gated potassium channel 2, hyperpolarization-activated cation channel 1, hyperpolarization-activated, cyclic nucleotide-gated K+ 2, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, trls
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
114244, 15166
Content And Storage
4° C, do not freeze
Form
Liquid
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Description
- Description: This QQA 4A6 monoclonal antibody recognizes mouse and rat HCN2
- QQA 4A6 detects a ∽95 kDa band corresponding to HCN2 by Western Blot
- An off target band of ∽80 kDa is detected in cell line models
- Applications Reported: This QQA 4A6 antibody has been reported for use in western blot and immunohistochemical staining
- Applications Tested: This QQA 4A6 antibody has been tested by western blot and may be used at less than or equal to 1.0 μg/mL The QQA 4A6 antibody has been tested by immunohistochemistry of frozen mouse tissue sections and can be used at less than or equal to 40 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Hyperpolarization-activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain
- HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides
- HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations
- The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus
- HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body
- These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.