NUP88 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
NUP88
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
Q8CEC0, Q99567
Gene ID (Entrez)
19069, 4927
Immunogen
Recombinant Mouse NUP88 protein, Leu57-Gly296 (Accession #Q5QNU0)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
0.5 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
88 kDa nuclear pore complex protein, 88 kDa nucleoporin, karyoporin, nuclear pore complex protein 88, nuclear pore complex protein Nup88, nucleoporin 88, nucleoporin 88kDa, nucleoporin Nup84, Nucleoporin Nup88, Nup84, NUP88, Prei2, preimplantation protein 2
Gene Symbols
NUP88
Isotype
IgG
Purification Method
Protein A
Gene
NUP88
Related Products
Description
- The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits
- Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG)
- Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex
- Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis
- The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.