200020124
IL-15 Monoclonal Antibody (C6), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
IL-15
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
AI503618, il 15, Il15, IL-15, ILN, Interleukin, interleukin 15, Interleukin15, interleukin-15, MGC9721, M-IL-15
Gene Symbols
IL15
Isotype
IgG κ
Purification Method
Protein A/G
Gene
IL15
Clone
C6
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Porcine
Gene Accession No.
P40933, Q95253
Gene ID (Entrez)
3600, 397683
Immunogen
Recombinant Human IL15 protein, Trp50-Ser162 (Accession #P40933)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation
- IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity
- The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2
- IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6
- In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis
- IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules
- As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases
- Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases
- Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.