HPD Monoclonal Antibody (D2), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
HPD
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
4H GLOD3, 4-H HPPDASE, 4HPPD, 4-HPPD, 4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid dioxygenase, 4-hydroxyphenylpyruvic acid oxidase, f Alloantigen, F liver antigen, f protein, Fla, Flp, GLOD3, glyoxalase domain containing 3, HPD, Hppd, HPPDASE, Laf, PPD
Gene Symbols
Hpd
Isotype
IgG2a κ
Purification Method
Protein A/G
Gene
Hpd
Clone
D2
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Porcine
Gene Accession No.
P32754, Q02110
Gene ID (Entrez)
3242, 397443
Immunogen
Recombinant Human HPD protein, Thr2-Met393 (Accession #P32754)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli
- All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3)
- Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli
- This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4)
- Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus
- The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.