IDO Monoclonal Antibody (C14), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
IDO
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
EC 1.13.11.52, IDO, IDO1, IDO-1, INDO, indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, indoleamine, indoleamine 2,3-dioxygenase 1, indoleamine 23-dioxygenase, Indoleamine-2, indoleamine-pyrrole 2,3 dioxygenase, indoleamine-pyrrole 2,3-dioxygenase
Gene Symbols
Ido1
Isotype
IgG2a κ
Purification Method
Protein A/G
Gene
Ido1
Clone
C14
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Porcine
Gene Accession No.
P14902
Gene ID (Entrez)
100519877, 3620
Immunogen
Recombinant Human IDO protein, Ala2-Gly403 (Accession #P14902)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin
- By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines
- IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs)
- In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction
- The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms
- Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites
- Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.