CD103 (Integrin alpha E) Monoclonal Antibody (2E7), Brilliant Ultra Violet™ 615, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD103 (Integrin alpha E)
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias
A530055J10, alpha-E1, alpha-M290, aM290, antigen CD103, antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide, CD103, DC, DCs, HML-1 antigen, human mucosal lymphocyte antigen 1, alpha polypeptide, HUMINAE, integrin alpha E, integrin alpha E, epithelial-associated, integrin alpha E1, epithelial-associated, integrin alpha M290, Integrin alpha-E, Integrin alpha-E heavy chain, Integrin alpha-E light chain, Integrin alpha-IEL, integrin subunit alpha E, integrin, alpha E, integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide), integrin, alpha E, epithelial-associated, Intregrin alpha E2, Itgae, MGC141996, Mucosal lymphocyte 1 antigen
Gene Symbols
Itgae
Primary or Secondary
Primary
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Clone
2E7
Applications
Flow Cytometry
Conjugate
Brilliant Ultraviolet 615
Host Species
Armenian Hamster
Target Species
Mouse
Gene Accession No.
Q60677
Gene ID (Entrez)
16407
Isotype
IgG
Purification Method
Affinity chromatography
Gene
Itgae
Related Products
Description
- CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells
- In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain
- CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs
- CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes
- CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
- ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains
- In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen
- CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation
- Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.