200020299
CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), Brilliant Violet™ 421, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD279 (PD-1)
Concentration
5 μL/Test
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias
CD279, EGK_05005, hPD1, hPD-1, hPD-l, hSLE1, Ly101, mPD-1, PD1, PD-1, Pdc1, Pdcd1, programmed cell death 1, programmed cell death 1 protein, programmed cell death protein 1, programmed cell death protein 1-like, programmed death 1, Protein PD1, protein PD-1, sCD279, SLEB2, soluble CD279, systemic lupus erythematosus susceptibility 2
Gene Symbols
Pdcd1
Primary or Secondary
Primary
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Clone
eBioJ105 (J105)
Applications
Flow Cytometry
Conjugate
Brilliant Violet 421
Host Species
Mouse
Target Species
Human, Rhesus Monkey
Gene Accession No.
Q15116
Gene ID (Entrez)
100135775, 5133
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Gene
Pdcd1
Related Products
Description
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC)
- T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC
- PD-1 can bind two different but related ligands, PDL-1 and PDL-2
- Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "edanger signals"e such as LPS or other molecules associated with bacteria or other pathogens
- Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases
- Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.