MPZ Monoclonal Antibody (C13), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
MPZ
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
Charcot-Marie-Tooth neuropathy 1B, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, myelin protein P0, Myelin protein zero, myelin protein zero (Charcot-Marie-Tooth neuropathy 1B), P0, P-zero
Gene Symbols
MPZ
Isotype
IgG3 κ
Purification Method
Protein A/G
Gene
MPZ
Clone
C13
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse, Porcine, Rat
Gene Accession No.
P06907, P25189, P27573
Gene ID (Entrez)
100153273, 17528, 24564, 4359
Immunogen
Recombinant Human MPZ protein, Ile30-Lys248 (Accession #P25189)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission
- Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin
- Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation
- Mutations (e.g
- G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease
- Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination
- Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.