Calnexin Monoclonal Antibody (C2), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Calnexin
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
1110069N15Rik, AI988026, calmegin, calnexin, canx, canx-a, canx-b, clgn, clnx, cnx, D11Ertd153e, FLJ26570, hypothetical protein, IP90, Major histocompatibility complex class I antigen-binding protein p88, p88, P90, PP90, pp90 precursor
Gene Symbols
CANX
Isotype
IgG2b κ
Purification Method
Protein A/G
Gene
CANX
Clone
C2
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Bovine, Canine, Human, Porcine, Rat
Gene Accession No.
P24643, P27824, P35565
Gene ID (Entrez)
100519184, 29144, 403908, 407129, 821
Immunogen
Recombinant Human CNX protein, Thr239-Ala461 (Accession #P27824)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER)
- Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins
- Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes
- It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER
- The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase
- Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention
- Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).