Galectin 12 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Galectin 12
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Porcine
Gene Alias
AW987437, GAL12, gal-12, galectin 12, galectin-12, Galectin-related inhibitor of proliferation, galectin-related inhibitor of proliferation 1, GRIP1, lectin, galactose binding, soluble 12, lectin, galactoside binding soluble 12, lectin, galactoside-binding, soluble, 12, LGALS12, testicular secretory protein Li 26
Gene Symbols
LGALS12
Isotype
IgG
Purification Method
Protein A
Gene
LGALS12
Concentration
0.5 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene ID (Entrez)
100217395
Immunogen
Recombinant Pig GAL12 protein, Met1-Tyr314 (Accession #B7U2G9)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- Galectin-12, also designated galectin-related inhibitor of proliferation 1 in mouse, is a 314 amino acid protein encoded by the human gene LGALS12
- Galectin-12 is a member of the galectin family consisting of b-galactoside-binding proteins with conserved carbohydrate recognition domains
- Galectin-12 binds lactose and may participate in the apoptosis of adipocytes
- This protein is preferentially expressed in peripheral blood leukocytes and adipocytes
- Galectin-12 is induced by cell cycle block at the G1 phase and causes G1 arrest when overexpressed
- The galectin-12 gene is expressed in mouse preadipo-cytes and is upregulated when preadipocytes undergo cell cycle arrest, concomitant with acquisition of the competence to undergo differentiation in response to adipogenic hormone stimulation
- Galectin-12 is an adipocyte-expressed protein which is downregulated by various insulin resistance-inducing hormones
- As a result, galectin-12 may play a role in the pathogenesis of insulin resistance.