3968634
CD11b/Mac-1 Mouse anti-Human, V450, Clone: ICRF44, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11b
Applications
Flow Cytometry
Conjugate
Violet Fluor 450 (V450)
Regulatory Status
RUO
Target Species
Human
Immunogen
Human monocytes
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
ICRF44
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Immunology
Formulation
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
Mac-1α, integrin αM subunit, CR3 α chain
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Description
- The ICRF44 monoclonal antibody reacts with CD11b, the 165kDa adhesion glycoprotein that associates with the 95kDa integrin β2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3
- CD11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells
- CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3)
- This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP
- The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences
- It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm
- Conjugates with BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates
- Host Species: Mouse Clone: ICRF44 (also known as 44) Isotype: IgG1 κ Species Reactivity: Human Immunogen: Human monocytes Flow Cytometry