c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD

Description

• The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc
• C-myc plays a role in proliferation, transformation, and differentiation
• It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas
• Cellular localization has been described as nuclear and/or cytopasmic
• C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region
• It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein
• Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation
• DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation
• C-myc migrates at 62 kDa in SDS-PAGE
• Clone 9E10 recognizes human c-myc
• A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.