4536540
α-1-Antitrypsin Ab-1 Rabbit Polyclonal Antibody, Epredia™
Obtain accurate, reproducible results with Epredia™ α-1-Antitrypsin Ab-1, Rabbit Polyclonal Antibody.
Manufacturer: Fischer Scientific
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Antigen
alpha-1-Antitrypsin Ab-1
Classification
Polyclonal
Host Species
Rabbit
Research Discipline
Enzyme
Immunogen
Purified human serum alpha-1-AT
Primary or Secondary
Primary
Applications
Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Baboon, Equine, Human, Mink
Isotype
IgG
Related Products
Description
- Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung
- In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma
- Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn
- Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation
- Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis
- Host Species: Rabbit Isotype: IgG Species Reactivity: Human, Baboon, Monkey, Horse and Mink
- Does not react with cow, kangaroo, pig, goat, sheep, cat, dog, guinea pig, mouse and chicken
- Others not known
- Immunogen: Purified human serum α-1-AT Positive Control: Tonsil Cellular Localization: Cytoplasmic Recommended for: Immunohistochemistry (Formalin/paraffin) Note: USA: RUO; Int'l: RUO