4542568
Estrogen Receptor Ab-17 Rabbit Polyclonal Antibody, Epredia™
Epredia™ Estrogen Receptor Ab-17, Rabbit Polyclonal Antibody provides accurate, reproducible results.
Manufacturer: Fischer Scientific
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Antigen
Estrogen Receptor Ab-17
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Research Discipline
Steroids Hormones and Growth Factors
Immunogen
A synthetic peptide from the N-terminus of human estrogen receptor, alpha protein
Primary or Secondary
Primary
Concentration
1mg/mL
Classification
Polyclonal
Form
Concentrated
Regulatory Status
RUO
Target Species
Bovine, Human, Mouse, Porcine, Rabbit, Rat
Isotype
IgG
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Description
- Description The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition
- The ER is an important regulator of growth and differentiation in the mammary gland
- Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g
- tamoxifen) therapy
- Host Species: Rabbit Isotype: IgG Species Reactivity: Human, Rat, Mouse, Rabbit, Sheep, Pig and Cow
- Others not known
- Epitope: N-terminal Immunogen: A synthetic peptide from the N-terminus of human estrogen receptor, α protein Molecular Weight: 67 kDa Positive Control: MCF-7 cells, Breast CA Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunoprecipitation (Denatured verified) Note: USA: RUO; Int'l: RUO