4542647
Factor VIII Related Antigen/von Willebrand Factor Ab-1 Rabbit Polyclonal Antibody, Epredia™
Obtain accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.
Manufacturer: Fischer Scientific
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Antigen
Factor VIII Related Antigen/von Willebrand Factor Ab-1
Classification
Polyclonal
Host Species
Rabbit
Research Discipline
Hematopoietic
Immunogen
Purified factor VIII related antigen/von Willebrand factor
Primary or Secondary
Primary
Applications
Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Regulatory Status
IVD
Target Species
Human
Isotype
IgG
Related Products
Description
- Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein
- It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin
- von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules
- It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII
- von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms
- As not all endothelial cells synthesize/store this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant
- Staining for factor VIII related antigen has also been used to measure angiogenesis an indicator of tumor recurrence
- Host Species: Rabbit Isotype: IgG Species Reactivity: Human
- Others not known
- Epitope: Not determined Immunogen: Purified factor VIII related antigen/von Willebrand factor Molecular Weight: 270 kDa Positive Control: Tonsil Cellular Localization: Cytoplasmic Recommended for: Immunohistochemistry (Formalin/paraffin) Immunofluorescence