4544016
Epredia™ Lab Vision™ Cytokeratin 17 Ab-1, Mouse Monoclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Epredia™ Cytokeratin 17 Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Fischer Scientific
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Antigen
Cytokeratin 17 Ab-1
Applications
Immunofluorescence, Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Regulatory Status
IVD
Target Species
Human, Rat
Isotype
IgG2b κ
Clone
E3
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cytoskeletal Protein
Immunogen
Keratin preparation from rat enterocytes
Primary or Secondary
Primary
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Description
- The type I keratin 17 (K17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life
- Additionally K17 is induced, along with K6 and K16, early after acute injury to human skin
- Predominant expression of K17 and the frequent expression of K8 and K19, with little K6/K16 and K1/K10 expression are the characteristic features of basal cell carcinomas (BCC), suggesting that BCC is differentiated towards undifferentiated follicular epithelia, most probably hair bulge cells
- Host Species: Mouse Clone: E3 Isotype: IgG2b/κ Species Reactivity: Human and Rat
- Others not known
- Epitope: Not determined Immunogen: Cytokeratin preparation from rat enterocytes Molecular Weight: 46 kDa Positive Control: Squamous cell CA, Skin Cellular Localization: Cytoplasmic Recommended for: Immunohistochemistry (Formalin/paraffin) Immunofluorescence