4555632
Epredia™ Lab Vision™ p53 Rabbit Monoclonal Antibody (Clone SP5)
Employ part of a comprehensive antibody portfolio with the Epredia™ p53, Rabbit Monoclonal Antibody (Clone SP5). Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.
Manufacturer: Fischer Scientific
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Antigen
p53
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
IVD
Immunogen
Recombinant human full-length wild type p53 protein
Clone
SP5
Classification
Monoclonal
Host Species
Rabbit
Research Discipline
Cancer and Tumor Biology
Primary or Secondary
Primary
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Description
- Description p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis
- It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair
- Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma
- Host Species: Rabbit Clone: SP5 Isotype: IgG Species Reactivity: Human
- Others not tested
- Epitope: Not determined Immunogen: Recombinant human full-length wild type p53 protein Molecular Weight: 53kDa Positive Control: MDA-231 cells, Colon CA Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting