4563344
TIMP-2 Ab-5 Mouse Monoclonal Antibody, Epredia™
Provide accurate, reproducible results with the Epredia™ TIMP-2 Ab-5, Mouse Monoclonal Antibody.
Manufacturer: Fischer Scientific
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Antigen
TIMP-2 Ab-5
Applications
Immunohistochemistry (Paraffin), Western Blot
Host Species
Mouse
Research Discipline
Proteases And Inhibitors
Immunogen
A synthetic peptide from the N-terminal region of human TIMP-2 protein
Primary or Secondary
Primary
Clone
3A4
Classification
Monoclonal
Regulatory Status
RUO
Target Species
Bovine, Guinea Pig, Human, Mouse, Rabbit, Rat
Isotype
IgG2a κ
Related Products
Description
- TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity
- TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A)
- It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B)
- TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells
- Host Species: Mouse Clone: 3A4 Isotype: IgG2a/κ Species Reactivity: Human, Mouse, Rat, Rabbit, Cow and Guinea Ppig
- Others not known
- Epitope: N-terminal Immunogen: A synthetic peptide from the N-terminal region of human TIMP-2 protein Molecular Weight: 21kDa Positive Control: Conditioned, serum-free medium from (TPA-treated) HFL-1 cells; Pancreatic or colon CA Cellular Localization: Cytoplasmic Recommended for: Immunohistochemistry (Formalin/paraffin only) Western Blotting Immunoprecipitation (Not suitable) Note: USA: RUO; Int'l: RUO