CD215 (IL-15Ra) Monoclonal Antibody (DNT15Ra), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 46-714-982-Each-of-1 | In Stock | ₹ 35,600.00 |
46-714-982 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,600.00
GST (18%): ₹ 6,408.00
Total Price: ₹ 42,008.00
Antigen
CD215 (IL-15Ra)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q60819
Gene Symbols
IL15RA
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16169
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
DNT15Ra
Conjugate
PerCP-eFluor 710
Gene
IL15RA
Gene Alias
AA690181; CD215; IL 15 receptor; IL 15 receptor subunit a; IL 15R; IL 15R alpha; IL 15R a; IL15 receptor; IL15 receptor subunit alpha; IL-15 receptor subunit alpha; IL15 receptor subunit a; IL15R; IL15R alpha; IL15R a; Il15ra; IL-15RA; IL-15R-alpha; Interleukin 15 receptor; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4; interleukin 15 receptor alpha isoform IC5; interleukin 15 receptor alpha isoform IC6; interleukin 15 receptor alpha isoform IC7; interleukin 15 receptor alpha isoform IC8; interleukin 15 receptor subunit alpha; Interleukin 15 receptor subunit a; interleukin 15 receptor, alpha; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; sIL 15R; sIL-15 receptor subunit alpha; sIL15R; sIL-15RA; sIL-15R-alpha; soluble IL 15R; soluble IL15R; Soluble interleukin-15 receptor subunit alpha
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- This DNT15Ra antibody reacts with alpha subunit of Mouse IL-15 Receptor
- The IL-15 Receptor alpha subunit is unique to IL-15, while the other two subunits of the receptor, beta and gamma, are shared with IL-2
- IL-15R signaling is mediated by Jak/STAT pathways, and results in the activation of neutrophils, dendritic cells, and macrophages
- IL-15 has also been found to play a critical role in the development and survival of NK cells and CD8+ T cells
- Although high levels of mouse IL-15 mRNA have been observed in many cell types, free IL-15 is rarely detectable in biological samples
- Recent research suggests that IL-15 is retained inside the cell and only secreted in complex with IL-15 Receptor alpha
- This chaperoning is necessary from the ER to the Golgi, through secretion
- The cytokine/receptor complex may stay bound to the cell surface, where it can be trans-presented to cells expressing the beta-gamma subunits of the receptor, or can be secreted in a soluble form lacking the transmembrane domain of IL-15 Receptor alpha
- IL-15 and IL-15 Receptor alpha are expressed by dendritic cells and macrophages in response to inflammatory stimuli
- Our testing suggests that there may be strain differences in expression and staining of the Mouse IL-15 Receptor alpha
- This DNT15Ra antibody has been tested on cells from C57Bl/6 mice
- Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity
- IL-15 regulates T and natural killer cell activation and proliferation
- The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding
- Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits
- IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.