CD215 (IL-15Ra) Monoclonal Antibody (eBioJM7A4), FITC, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-2156-Each-of-1 | In Stock | ₹ 31,684.00 |
50-112-2156 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,684.00
GST (18%): ₹ 5,703.12
Total Price: ₹ 37,387.12
Antigen
CD215 (IL-15Ra)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q13261
Gene Symbols
IL15RA
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3601
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
eBioJM7A4
Conjugate
FITC
Gene
IL15RA
Gene Alias
AA690181; CD215; IL 15 receptor; IL 15 receptor subunit a; IL 15R; IL 15R alpha; IL 15R a; IL15 receptor; IL15 receptor subunit alpha; IL-15 receptor subunit alpha; IL15 receptor subunit a; IL15R; IL15R alpha; IL15R a; Il15ra; IL-15RA; IL-15R-alpha; Interleukin 15 receptor; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4; interleukin 15 receptor alpha isoform IC5; interleukin 15 receptor alpha isoform IC6; interleukin 15 receptor alpha isoform IC7; interleukin 15 receptor alpha isoform IC8; interleukin 15 receptor subunit alpha; Interleukin 15 receptor subunit a; interleukin 15 receptor, alpha; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; sIL 15R; sIL-15 receptor subunit alpha; sIL15R; sIL-15RA; sIL-15R-alpha; soluble IL 15R; soluble IL15R; Soluble interleukin-15 receptor subunit alpha
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Related Products
Description
- Description: The eBioJM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Ralpha)
- IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects
- Their receptors share 2 subunits, the IL-2Rbeta and gamma chains, which are essential for signal transduction
- The IL-15Ralpha receptor is structurally related to IL-2Ralpha
- However, the IL-15Ralpha alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2Ralpha and IL-2
- In the human, 3 differentially spliced human IL-15Ralpha variants that are all capable of high affinity binding of IL-15 have been isolated
- The cytoplasmic domain of IL-15Ralpha, like that of IL-2Ralpha, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding
- At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL-2Rbeta and IL-2Rgamma in the absence of the alpha subunit
- Applications Reported: This eBioJM7A4 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This eBioJM7A4 antibody has been pre-titrated and tested by flow cytometric analysis of LPS and IFN gamma-stimulated normal human peripheral blood cells
- This can be used at 5 μL (0.5 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity
- IL-15 regulates T and natural killer cell activation and proliferation
- The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding
- Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits
- IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.