4747116
CD4 Mouse anti-Human, BUV395, Clone: SK3, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD4
Applications
Flow Cytometry
Conjugate
Brilliant Ultraviolet 395
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
L3T4; Leu3a; T-cell surface antigen T4/Leu-3 ; W3/25 ; CD4 antigen (p55)
Clone
SK3
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human Peripheral Blood T Cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The SK3 monoclonal antibody specifically binds to CD4
- The CD4 antigen is a 55 kDa type 1 transmembrane glycoprotein that belongs to the immunoglobulin superfamily
- It is expressed on T-helper/inducer lymphocytes and monocytes
- CD3+CD4+ T cells comprise approximately 28% to 58% of normal peripheral blood lymphocytes
- CD4 is also expressed on 80% to 95% of normal thymocytes
- The CD4 antigen is present in low density on the cell surface of monocytes and in the cytoplasm of monocytes and macrophages (CD3-CD4+)
- CD4 serves as a T cell coreceptor for MHC class II antigen recognition and as a receptor for the human immunodeficiency virus (HIV)
- The SK3 antibody inhibits HIV binding to CD4+ cells
- The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument
- With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector
- BD Horizon™ BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.