CD112 (Nectin-2) Monoclonal Antibody (R2.477), APC, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-3070-Each-of-1 | In Stock | ₹ 32,930.00 |
50-112-3070 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,930.00
GST (18%): ₹ 5,927.40
Total Price: ₹ 38,857.40
Antigen
CD112 (Nectin-2)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q92692
Gene Symbols
NECTIN2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5819
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
R2.477
Conjugate
APC
Gene
NECTIN2
Gene Alias
AI325026; AI987993; CD112; herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; MPH; Murine herpes virus entry protein B; murine herpesvirus entry protein B; nectin cell adhesion molecule 2; Nectin2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; poliovirus sensitivity; PRR2; Pvr; Pvrl2; PVRR2; Pvs
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: This R2.477 monoclonal antibody reacts with human CD112 (also known as Nectin-2 or Poliovirus Receptor Related 2), a 60-65 kDa immunoglobulin-like transmembrane cell adhesion molecule
- This cell surface molecule is expressed on hematopoietic cells, endothelial, epithelial, as well as tumor cell lines such as Jurkat, U937, and MCF7
- CD112 is a ligand for DNAM-1 (CD226), a leukocyte adhesion molecule expressed on natural killer (NK) cells
- Interaction between CD112 and DNAM-1 promotes NK cytotoxic activity, leading to tumor cell lysis
- In addition to its role in tumor suppression, CD112 plays a cooperative role in cell-cell adhesion, particularly in the formation of adherens junctions between neighboring epithelial cells and fibroblasts
- CD112 can form homophilic and heterophilic interactions to regulate contact inhibition of cell movement and proliferation
- Finally, CD112 has been reported to be a receptor for herpesvirus entry into cells
- This monoclonal antibody has been reported to block cell adhesion and herpesvirus entry
- Applications Reported: This R2.477 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This R2.477 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood cells
- This can be used at 5 μL (0.25 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain
- This protein is one of the plasma membrane components of adherens junctions
- It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses
- Variations in this gene have been associated with differences in the severity of multiple sclerosis
- Alternate transcriptional splice variants, encoding different isoforms, have been characterized.