CCL3 (MIP-1 alpha) Monoclonal Antibody (DNT3CC), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-3908-Each-of-1 | In Stock | ₹ 35,333.00 |
50-112-3908 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,333.00
GST (18%): ₹ 6,359.94
Total Price: ₹ 41,692.94
Antigen
CCL3 (MIP-1 alpha)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P10855
Gene Symbols
Ccl3
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20302
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
DNT3CC
Conjugate
PerCP-eFluor 710
Gene
Ccl3
Gene Alias
AI323804; C-C motif chemokine 3; C-C motif chemokine ligand 3; CCL3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; Heparin-binding chemotaxis protein; H-MIP-1-alpha; L2G25B; LD78ALPHA; LD78-alpha; LD78-alpha(4-69); Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP1 (a); mip1 alpha; MIP-1 alpha; MIP1-(a); MIP1A; MIP-1a; MIP-1alpha; MIP-1-alpha; MIP1-alpha; MIP-1-alpha(4-69); PAT 464.1; RP23-320E6.7; Scya3; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This DNT3CC monoclonal antibody reacts with mouse CCL3
- CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta
- These proteins play critical roles in the recruitment of leukocytes to the site of inflammation
- While both CCL3 and CCL4 will attract monocytes, macrophages, and dendritic cells, CCL3 preferentially attracts CD8+ T cells, while CD4+ T cells are more responsive to CCL4
- In addition to its chemotactic functions, CCL3 induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation
- It has also been reported to inhibit hematopoetic stem cell proliferation and may be responsible for the maintece of these cells in a quiescent state
- CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES)
- Applications Reported: This DNT3CC antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This DNT3CC antibody has been tested intracellular staining of stimulated mouse spleen cells followed by flow cytometric analysis using the Intracellular Fixation & Permeabilization Buffer Set (cat
- 88-8824) and protocol
- Please refer to Best Protocols: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins
- This can be used at less than or equal to 0.5 μg per test
- Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines
- They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g
- macrophages, lymphocytes and NK cells)
- While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes
- Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells
- Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.