50-121-82
IL-13 Monoclonal Antibody (eBio1316H), Biotin, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-121-82-Each-of-1 | In Stock | ₹ 31,684.00 |
50-121-82 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,684.00
GST (18%): ₹ 5,703.12
Total Price: ₹ 37,387.12
Antigen
IL-13
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P20109
Gene Symbols
Il13
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16163
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
ELISA
Clone
eBio1316H
Conjugate
Biotin
Gene
Il13
Gene Alias
ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600
Host Species
Rat
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The eBio1316H antibody reacts with mouse IL-13
- The eBio1316H antibody is a neutralizing antibody
- Mouse interleukin-13 (IL-13), originally designated p600, is a 11.6 kDa protein secreted by activated T helper cells, CD8+ T cells, and NK cells
- IL-13 was originally identified in 1989 through differential hybridization of cDNA libraries prepared from T helper 1 and T helper 2 cells
- IL-13 contains four cysteine residues, which form two intramolecular disulfide bonds
- IL-13 shares many activities with IL-4; this relates to a requirement for IL-4Ralpha chain for signal transduction
- The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression, and suppression of inflammatory cytokine expression
- IL-13 induces CD23 expression on B cells and enhances CD72, and expression of class II MHC gene products
- Mouse IL-13 does not display the activities on T cells and B cell stimulatory effects which IL-4 exhibits
- Mouse IL-13 is active on human and mouse cells
- Applications Reported: The eBio1316H antibody has been reported useful for neutralization, ELISA detection, and ELISPOT detection
- Applications Tested: The biotinylated eBio1316H antibody has been tested as the detection antibody in a sandwich ELISA (and ELISPOT assay) for analysis of mouse interleukin-13 (IL-13) in combination with the purified eBio13A (14-7133) antibody for capture and recombit mouse IL-13 (14-8131) as the standard
- IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses
- IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils
- IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells
- Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF
- The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.