CD152 (CTLA-4) Monoclonal Antibody (14D3), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-129-19-Each-of-1 | In Stock | ₹ 18,156.00 |
50-129-19 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 18,156.00
GST (18%): ₹ 3,268.08
Total Price: ₹ 21,424.08
Antigen
CD152 (CTLA-4)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P16410
Gene Symbols
CTLA4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1493, 705673
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Neutralization
Clone
14D3
Conjugate
Unconjugated
Gene
CTLA4
Gene Alias
ALPS5; CD; CD152; CD152 antigen; CD152 isoform; CD152 protein; CD152 protein precursor; celiac disease 3; CELIAC3; Ctla4; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte associated protein 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; EGK_04712; GRD4; GSE; ICOS; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ly-56; sCTLA4; soluble form; transmembrane form
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rhesus Monkey
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4)
- CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does
- CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation
- The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling
- The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity
- Applications Reported: The 14D3 antibody has been reported for use in flow cytometric analysis and immunoblotting (WB)
- 14D3 has also been reported in in vitro inhibition studies
- (Please use Functional Grade purified 14D3, cat
- 16-1529, in functional assays.)
- Applications Tested: The 14D3 antibody has been tested by intracellular staining and flow cytometric analysis of PHA stimulated normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (cat
- 88-8824) and protocol
- CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells
- It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28
- However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning
- Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.