Caspase 3 Monoclonal Antibody (MAR-1), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-177-09-Each-of-1 | In Stock | ₹ 31,150.00 |
50-177-09 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,150.00
GST (18%): ₹ 5,607.00
Total Price: ₹ 36,757.00
Antigen
Caspase 3
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2-7.4
Gene Accession No.
P42574
Gene Symbols
CASP3
Immunogen
Rec. Human Caspase-3
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
ELISA, Western Blot
Clone
MAR-1
Conjugate
Unconjugated
Gene
CASP3
Gene Alias
A830040C14Rik; AC-3; Apopain; Apopain precursor; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; cysteine protease; CPP32; apopain; ICE3; IRP; LICE; mLdy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
836
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Description: Caspases are present in all cells, recruitment of these proteases to oligomerized receptors leads to activation accompanied by autoproteolytic cleavage
- Active caspases can proteolyze additional caspases generating a caspase cascade that cleaves proteins critical for cell survival
- The final outcome of this signaling pathway is a form of controlled cell death termed apoptosis
- The subgroup of caspases involved in apoptosis is called initiators or effectors
- Caspase-3 cleaves substrate at the carboxyl terminus of aspartate residues
- Active caspase-3 has two active sites and consists of two identical large (∽ 20 kDa) and two identical small (∽ 10 kDa) subunits that are derived from two precursor caspase-3 polypeptides
- Caspase-3 is proteolytically activated by other caspases
- Both subunits contribute to substrate binding and catalysis
- The active site cysteine that covalently binds the substrate is located near the C-terminus of the large subunit
- Active caspase-3 has two-fold symmetry, two active site pockets each residing on an opposite side
- Caspase-3, together with caspases 8 and 9, is situated at pivotal junctions in apoptotic pathways
- Caspase-3 appears to amplify caspase 8 and 9 initiation signals into complete commitment to apoptotic disassembly
- Applications Tested: ELISA, Western Blotting
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme
- This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10
- It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease
- Alternative splicing of this gene results in two transcript variants that encode the same protein.