Phospho-FGFR1 (Tyr653, Tyr654) Rabbit anti-Human∣Mouse∣Rat, Polyclonal, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5220-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5220 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-FGFR1 (Tyr653, Tyr654)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
FGFR1
Gene Alias
2.7.10.1; AW208770; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R; bFGF-R-1; BOS_23880; CD331; CD331 antigen; CEK; CEK1; cek1 protein; c-fgr; Eask; ECCL; FGF receptor-1; FGFBR; Fgfr1; FGFR-1; FGFR1/PLAG1 fusion; FGFRI; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome); Flg; FLT2; FLT-2; Fms-like tyrosine kinase 2; fms-related tyrosine kinase 2; HBGFR; heparin-binding growth factor receptor; HH2; HRTFDS; Hspy; hydroxyaryl-protein kinase; KAL2; MFR; N-sam; OGD; Proto-oncogene c-Fgr; Tyrosine kinase receptor CEK1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
14182, 2260, 79114
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
P11362, P16092, Q04589
Gene Symbols
FGFR1
Immunogen
KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr653/654.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain
- FGFR1 has multiple isoforms and is a Type I membrane protein
- FGFR family members differ from one another in their ligand affinities and tissue distribution
- A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain
- The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation
- FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction
- FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform
- FGFR1 has been shown to interact with N-cadherin and NCAM
- Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR-1, FGFR-2, FGFR-3 and FGFR-4.FGFRs are members of the tyrosine kinase family of growth factor receptors
- At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain, vascular basement membrane and skin
- Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis
- Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome
- Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.