Phospho-Cyclin B1 (Ser126)Rabbit anti-Canine, Chimpanzee, Hamster, Human, Mouse, Rat, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-1759-Each-of-1 | In Stock | ₹ 52,930.08 |
50-199-1759 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,930.08
GST (18%): ₹ 9,527.414
Total Price: ₹ 62,457.494
Antigen
Phospho-Cyclin B1 (Ser126)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ccnb1
Gene Alias
Ccn-2; CCNB; CCNB1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
100770842, 25203, 268697, 461835, 608420, 891
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunoprecipitation, Western Blot
Concentration
2.01 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
P14635, P24860, P30277, Q08301
Gene Symbols
Ccnb1
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Chimpanzee, Hamster, Human, Mouse, Rat
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody is specific for phosphorylated human Cyclin B1 protein at the pS126 residue
- BLAST analysis indicates 100 % homology of the immunizing sequence with Cyclin B1 from human
- Cross reactivity may occur with Cyclin B1 from rat, dog and chimpanzee as only a single amino acid change was detected within the immunogen sequence from these sources (91% homology)
- Partial reactivity may also occur with Cyclin B1 from mouse and hamster where two amino acids changes was noted (83% homology)
- Minimal reactivity is expected with the non-phosphorylated form of the protein
- Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs)
- Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis
- It is essential for the control of the cell cycle at the G2/M transition
- Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF)
- Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase
- Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis
- Destruction of Cyclin B1 is required for cell cycle progression
- Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.