MBD1 Polyclonal Antibody, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-255-0798-Each-of-1 | In Stock | ₹ 35,600.00 |
50-255-0798 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,600.00
GST (18%): ₹ 6,408.00
Total Price: ₹ 42,008.00
Antigen
MBD1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MBD1
Gene Alias
CXXC3, CXXC-type zinc finger protein 3, Mbd1, methyl-CpG binding domain protein 1, methyl-CpG binding domain protein 1 isoform PCM1, methyl-CpG-binding domain protein 1, Methyl-CpG-binding protein MBD1, PCM1, Protein containing methyl-CpG-binding domain 1, RFT, the regulator of fibroblast growth factor 2 (FGF-2) transcription
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4152
Content And Storage
-20°, C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
ChIP Assay, ELISA, Western Blot
Concentration
0.7 mg/mL
Formulation
PBS with 0.1% BSA and 0.05% ProClin 300, 0.05% sodium azide
Gene Accession No.
Q9UIS9
Gene Symbols
MBD1
Immunogen
Raised against the human MBD1 protein.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
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Description
- Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA
- It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides
- Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS)
- MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1
- Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.