53-611-982
Tmem119 Monoclonal Antibody (V3RT1GOsz), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-611-982-Each-of-1 | In Stock | ₹ 39,160.00 |
53-611-982 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,160.00
GST (18%): ₹ 7,048.80
Total Price: ₹ 46,208.80
Antigen
Tmem119
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q8R138
Gene Symbols
TMEM119
Immunogen
cell surface peptide
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
V3RT1GOsz
Conjugate
Alexa Fluor 488
Gene
TMEM119
Gene Alias
AW208946; BC025600; OBIF; Osteoblast induction factor; PSEC0199; Tmem119; Transmembrane protein 119; UNQ731/PRO1415
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
231633
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- Description: This V3RT1GOsz monoclonal antibody recognizes mouse Tmem119
- This clone has been reported to be successfully used in flow cytometry
- Applications Reported: This V3RT1GOsz antibody has been reported for use in flow cytometric analysis
- Applications Tested: This V3RT1GOsz antibody has been tested by flow cytometric analysis of mouse brain cells after myelin removal
- This may be used at less than or equal to 1.0 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2
- Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages
- Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons
- They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment
- Microglia are particularly mobile in areas of the brain undergoing restructuring
- Reactive microglia co-express the marker Iba1
- In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis
- The specific function Tmem119 plays on microglial cells remains unclear
- Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.