MUC5AC Antibody (9-13M1), Novus Biologicals™

Mucin 5AC

0.2 mg/mL

Flow Cytometry, Immunohistochemistry (Frozen), SDS-Page, Immunofluorescence

Unconjugated

Mouse

Extracellular Matrix

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

4586

M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient.

Primary

Store at 4C.

9-13M1

Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Frozen 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 1 - 2 ug/ml

Monoclonal

Purified

RUO

Human

gastric mucin, leB, lewis B blood group antigen, major airway glycoprotein, MUC5, mucin 5, subtypes A and C, tracheobronchial/gastric, mucin 5AC, oligomeric mucus/gel-forming, mucin 5AC, oligomeric mucus/gel-forming pseudogene, mucin-5 subtype AC, tracheobronchial, mucin-5AC, TBM, tracheobronchial mucin

MUC5AC

IgG1 κ

Protein A or G purified

This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the N-terminal cysteine rich part of the peptide core of MUC5AC, which is heavily glycosylated. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. MAb 9-13M1 pairs with MAb 1-13M1 to measure MUC5AC protein by ELISA. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.