67-575-742
VSIG4 Monoclonal Antibody (JAV4), Super Bright™ 702, eBioscience™, Invitrogen™
Manufacturer: eBioscience
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 67-575-742-Each-of-1 | In Stock | ₹ 34,977.00 |
67-575-742 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,977.00
GST (18%): ₹ 6,295.86
Total Price: ₹ 41,272.86
Antigen
VSIG4
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9Y279
Gene Symbols
VSIG4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11326
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
JAV4
Conjugate
Super Bright 702
Gene
VSIG4
Gene Alias
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This JAV4 monoclonal antibody recognizes human V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig
- There are two variants of human VSIG4 that result from alternative splicing
- Isoform 1 is longer and more prevalent than isoform 2, and this JAV4 antibody recognizes both
- VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins
- It contains one complete V-type Ig domain and one truncated C-type Ig domain
- VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages
- It has been shown to bind complement components C3b and iC3b
- This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens
- VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation
- Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion
- Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4
- The JAV4 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized
- This antibody does not cross-react with mouse or rat VSIG4
- Applications Reported: This JAV4 antibody has been reported for use in flow cytometric analysis
- T cell activation by APCs is positively and negatively regulated by members of the B7 family
- VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production.