ADAM17 Recombinant Rabbit Monoclonal Antibody (3H46L1), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-307-7-Each-of-1 | In Stock | ₹ 38,270.00 |
70-307-7 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,270.00
GST (18%): ₹ 6,888.60
Total Price: ₹ 45,158.60
Antigen
ADAM17
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.4
Gene Accession No.
P78536, Q9Z0F8, Q9Z1K9
Gene Symbols
ADAM17
Immunogen
Protein corresponding to human ADAM17 [aa219-aa474]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
3H46L1
Conjugate
Unconjugated
Gene
ADAM17
Gene Alias
a disintegrin and metallopeptidase domain 17, a disintegrin and metalloprotease domain 17, a disintegrin and metalloproteinase, a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), ADAM, ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, Adam17, ADAM18, ADAMs, CD156B, CD156b antigen, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, metalloendopeptidases, NISBD, NISBD1, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
11491, 57027, 6868
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Rat, Bovine
- ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form
- ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein
- It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT)
- Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.