IFI16 Recombinant Rabbit Monoclonal Antibody (8H37L1), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-314-7-Each-of-1 | In Stock | ₹ 44,500.00 |
70-314-7 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,500.00
GST (18%): ₹ 8,010.00
Total Price: ₹ 52,510.00
Antigen
IFI16
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.4
Gene Accession No.
Q16666
Gene Symbols
IFI16
Immunogen
Protein corresponding to human IFI16 [1) aa571-aa766 2) aa446-aa571]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
8H37L1
Conjugate
Unconjugated
Gene
IFI16
Gene Alias
gamma-interferon-inducible protein 16, IFI 16C, IFI16, Ifi-16, IFNGIP1, interferon gamma inducible protein 16, interferon, gamma-inducible protein 16, interferon-gamma induced protein IFI 16, interferon-inducible myeloid differentiation transcriptional activator, PYHIN2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3428
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with Mouse, Rat, Bovine
- IFI16 (gamma-inteferon-inducible protein 16) binds double-stranded DNA
- It binds preferentially to supercoiled DNA and cruciform DNA structures
- It seems to be involved in transcriptional regulation and as a transcriptional repressor
- IFI16 may have a role in the regulation of hematopoietic differentiation through activation of unknown target genes
- It controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein
- IFI16 is also involved in innate immune response by recognizing viral dsDNA in the cytosol and nucleus
- After binding to viral DNA in the cytoplasm, IFI16 recruits TMEM173/STING and mediates the induction of IFN-beta
- It is necessary to activate the IFR3 signaling cascade suring human herpes simplex virus 1 infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibiton of viral immediate-early gene expression and replication
- IFI16 is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.