7092521
CD3 Molecular Complex Rat anti-Mouse, PE, Clone: 17A2, BD
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD3 Molecular Complex
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Rat
Research Discipline
Immunology
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype
IgG2b κ
Purification Method
Affinity Purified
Clone
17A2
Applications
Flow Cytometry
Conjugate
PE
Regulatory Status
RUO
Target Species
Mouse
Immunogen
γδ TCR-positive T-T hybridoma D1
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The 17A2 monoclonal antibody specifically binds to the T-cell receptor-associated CD3 complex that is expressed on many thymocytes and mature T lymphocytes
- Plate-bound 17A2 antibody has been reported to induce IL-2 production by cultured T cells in the absence of accessory cells
- The binding of the 17A2 antibody to T cells can be blocked by the anti-CD3e mAb 145-2C11
- This suggests that the 17A2 antibody recognizes an epitope of the CD3 epsilon chain
- In vivo treatment with 17A2 antibody has been reported to partially deplete T lymphocytes and temporarily down-modulates CD3 expression on T cells.