7143946
IDO1 Recombinant Rabbit Monoclonal Antibody (BLR031F), Bethyl Laboratories
Rabbit Recombit Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
IDO1
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P14902
Gene ID (Entrez)
3620
Immunogen
recombit protein representing Human IDO1
Primary or Secondary
Primary
Content And Storage
4° C
Gene
IDO1
Clone
BLR031F
Classification
Recombinant Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene Alias
IDO, INDO
Gene Symbols
IDO1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin
- By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines
- IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs)
- In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction
- The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms
- Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites
- Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.