7143997
CD31 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD31
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
CD31 antigen, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, CD31/EndoCAM, adhesion molecule, endoCAM, platelet endothelial cell adhesion molecule
Gene Symbols
PECAM1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P16284
Gene ID (Entrez)
5175
Immunogen
Between 700 and C-term
Primary or Secondary
Primary
Content And Storage
4° C
Gene
PECAM1
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases
- CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells
- N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions
- CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis
- It is one of key regulatory molecules in vascular system.