7144188
XPF/ERCC4 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
XPF/ERCC4
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
DNA excision repair protein ERCC-4, DNA repair endonuclease XPF, DNA repair protein complementing XP-F cells,excision-repair, complementing defective, in Chinese hamster, xeroderma pigmentosum group F-complementing protein, xeroderma pigmentosum, complementation group F
Gene Symbols
ERCC4
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q92889
Gene ID (Entrez)
2072
Immunogen
Between 855 and 905
Primary or Secondary
Primary
Content And Storage
4° C
Gene
ERCC4
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Monkey, Gorilla, Chimpanzee and Crab-eating macaque The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links
- NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases
- In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision
- ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.