CREB Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat, X
• laevis, X
• tropicalis, Chicken, Turkey, Sheep, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda and Orangutan CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors
• Activation of CREB is dependent upon the phosphorylation of serine 133
• Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1
• Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor
• CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133
• CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory
• In humans, the gene is located on the q arm of chromosome 2
• Diseases associated with CREB dysfunction include Alzheimer's Disease, histiocytoma and soft tissue melanoma.