7144280
CEP290 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CEP290
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
Centrosomal protein of 290 kDa, Cep290, Bardet-Biedl syndrome 14 protein, Cancer/testis antigen 87, CT87, Nephrocystin-6, Tumor antigen se2-2, CEP290, BBS14, KIAA0373, NPHP6
Gene Symbols
CEP290
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunocytochemistry, Immunofluorescence
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
O15078
Gene ID (Entrez)
80184
Immunogen
Between 2429 and 2479
Primary or Secondary
Primary
Content And Storage
4° C
Gene
CEP290
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Horse, Orangutan, Monkey, Gorilla, Northern white-cheeked gibbon, Small-eared galago and African CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes
- CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain
- There are two named isoforms
- Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5), Senior-Loken syndrome type 6 (SLSN6), Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4)
- Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.